Patofisiologi
In normal circumstances, the blood sugar glucose (KGD) in the fasting glucose is a product with the heart (GPH) and after the meal by absorbs extract food from the gut. If KGD increased, it will be immediately followed by a rise sekresi insulin from pancreas. Insulin will KGD down through two ways, namely: 1) The GPH and increase synthesis glycogen and 2) Improve the transportation (membrane effect), uptake and glucose metabolism in perifer network, especially networks of fat and muscle. Liver glucose products also influenced by hormones and glukagon will katekolamin that increase GPH, so these hormones are antagonise of insulin. Glucose itself can increase the GPH.
Thus, glucose homeostasis interference may come from a disruption in:
1) Pankreas, if sensitivitas of blood glucose decreased, or if its production and / or abnormal sekresi.
2) Network careful, because the increase in GPH interference suppress insulin, glucose, or because stimulation glukagon and katekolamin.
3) Network perifer, the target cells (target) becomes resistant to insulin which result in disruption of transportation and glucose metabolism.
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