hiv - aids 8 therapy

Therapy Anti retrovirus
Without giving medications anti retrovirus, 25% of infants with HIV-positive mothers will be born before or at the time of birth, or 15% will be through breastfeeding. (Pusponegoro, 2004)
Zidovudin (AZT) is a regimen that often use at this time as anti retrovirus therapy based on the results of PACTG 076 (Pediatric AIDS Clinical trials Group study - protocol 076). (Mofenson, 2007)
In the therapy anti retrovirus this, note whether the mother before being anti retrovirus obtain treatment for HIV or get treatment for the prevention of transmission anti retrovirus on the baby.
When mothers have got AZT 4 weeks before birth, after birth the baby is given AZT 2 mg / kg BB per oral every 6 hours for 6 weeks. When mothers have got nevirapin single dose during labor and infants aged less than 3 days, the baby should be given in nevirapin Suspense 2 mg / kg BB per oral. (Pusponegoro, 2004)
When there is no therapy anti retrovirus given to the mother during pregnancy, childbirth, or at the time of birth, there are some recommendations that include: (Mofenson, 2007)
• Babies should immediately get AZT therapy immediately after birth for 6 weeks, given in 6-12 minutes.
• specialist children's doctor who specifically deal with HIV need to consider combinations of drugs anti retrovirus depending on the status of the mother.
• Mother of the examination should be performed after childbirth (eg, viral load, the number of CD4 cells), to determine whether he should get therapy anti retrovirus for health itself.
Preparat and anti retrovirus dose for infants and children: (Wahono, 2006)
1. Zidovudin (AZT)
- Neonates less hours
1.5 mg / kg BB every 12 hours until the age of 2 weeks, then 2 mg every 8 hours kg BB
- Neonates enough hours (until the age of a baby 90 days) < • Oral: 2 mg / kgBB every 6 hours (oral) • IV: 1.5 mg / kgBB every 6 hours - Pediatrics (dose range 90 mg-180mg/m2 LPB every 6-8 hours) • Oral: 160 mg/m2 every 8 hours LPB • IV (infus intermiten): 120 mg/m2 every 6 hours LPB • IV (infus rumatan): 20 mg/m2 LPB / hr - Adolesen 3x200 mg / day, or 2x300 mg / day 2. Stavudin (d4T) - Neonatus (under evaluation in the PACTG 332) - Pediatrics 1 mg / kgBB (up to 30 kg weight), 2x a day - Adolesen / adult BB> 60 mg kg 2x40, BB <60> 50 kg: 2xl50 mg / day; BB <50>