Lung cancer can also spread through the bloodstream to the liver, brain, adrenal glands and bone. This can happen at an early stage, especially in small cell carcinoma. Symptoms of liver failure, confusion, seizures, and bone pain; that could arise before the occurrence of various lung disorders, so that early diagnosis difficult to enforce.
Some lung cancer effect in a place far away from the lungs, such as metabolic disorders, neurological disorders and muscle disorders (paraneoplastik syndrome). This syndrome is not related to the size and location of the cancer and does not necessarily indicate that the cancer has spread outside the chest; syndrome is caused by substances released by cancer. The symptoms can be an early sign of cancer or a preliminary indication that the cancer had returned, after such treatment. One example of the syndrome is paraneoplastik Eaton-Lambert syndrome, characterized by muscle weakness extraordinary. Another example is the muscle weakness and pain due to inflammation (polimiositis), which may be accompanied by inflammation of the skin (dermatomiositis).
Some lung cancer hormone or hormone-like substances, resulting in high levels of the hormone.
Small cell carcinoma producing corticotropin (causing Cushing's syndrome) or antidiuretic hormone (causing fluid retention and low sodium levels in the blood). The formation of excessive hormones can also cause carcinoid syndrome, namely redness, wheezing breath sounds, diarrhea and heart valve abnormalities. Squamous cell carcinoma releasing hormone-like substances that cause blood calcium levels are very high.
Other hormonal syndrome associated with lung cancer are:
- Breast enlargement in men (gynecomastia)
- Excess thyroid hormone (hyperthyroidism)
- Changes in the skin (skin in the armpit become darker).
Lung cancer can also cause changes in the form of fingers and toes and change at the end of long bones, which can be seen on x-rays.
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