Etiology and Patogenesis
The cause of the basic findings on the initial clinical form of diabetes is dominant at the time the child is secresi of insulin to decrease sharply. Although the degree basalt in plasma insulin can be normal in people with newly diagnosed, insulin production in respon against various secret revealed a strong and usually disappear after many months or many years, rarely exceed 5 years. On certain people who are considered high risk for the development of type 1 diabetes, such as identical twin is not affected by diabetes, a progressive decrease in the capacity as secresi have known for months to many years before showing clinical symptoms of diabetes, which usually become visible at the time of backup secresi insulin or 20% less than normal.
There is evidence indicating that the etiology of diabetes mellitus manifold. Although various types of lesi with different will eventually lead to insulin insufiensi, but the genetic determinan usually play an important role in the majority of people with diabetes mellitus. Insulin dependent diabetes mellitus (DMTI) is a disease that otoimun determined genetic.
Mechanisms that cause the failure of ß cell function of the pancreas to the possibility of damage autoimmune on the islands in the pancreas that have a tendency of individuals. Diabetes mellitus type 1 has long been known to increase in prevalence in people with diseases such as Addison aberration, tiroiditis Hashimoto, and pernicious anemia, which is known autoimun mechanism patogenik. Diabetes mellitus type 1 insulin dependent also be associated with increased frequency of certain HLA, especially HLA-B8,-DR3,-BW15, and-DR4. Located on chromosome 6, the HLA system histokompatibilitas major complex consisting of a group of genes that code transplantation antigen and plays a central role in the immune response.
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